Endocannabinoid System & CBD and how they work together.
It appears the main function of the endocannabinoid system is to maintain bodily homeostasis—biological harmony in response to changes in the environment.9 Taxonomic investigation revealed that the endocannabinoid system is incredibly old, having evolved over 500 million years ago. Moreover, it is present in all vertebrates—mammals, bird, reptiles, amphibians, fish, etc, all produce endocannabinoids!10
The endocannabinoid system also works at the intersection of different systems, and it is the means by which different cells communicate and coordinate with each other. Although the cannabinoid receptors are found throughout the body, they are clustered around specific systems. The CB1 receptor, for example, exists largely in the nervous system, glands, connective tissues, and organs, while the CB2 receptors are mostly found in the immune system and its related organs.
CBD and Receptors
CBD acts upon CB1 and CBD2 receptors located throughout the body to produce a variety of potentially positive outcomes. … By stimulating the endocannabinoid system, CBD promotes homeostasis by helping the ECS, reduces pain sensation and decreases inflammation.
A neat example of this is when an injury occurs. At the moment of cellular trauma, the endocannabinoid system helps stabilize the nervous system to prevent excess firing (pain) and manages the immune response to prevent excessive inflammatory substances from being released.
The ECS exists and is active in your body even if you don’t use cannabis, endocannabinoids are designed to help maintain the health level of the body. If that level decreases; however, theoretically, they would only maintain the existing health level and may not be enough to prevent it from decreasing further. Over time, the health level could decrease little by little, slowly growing into a bigger health problem.
This is where phytocannabinoids like CBD come in, if the body suffers from cannabinoid deficiency, administering CBD can help equalize the deficiency (studies suggest that cannabinoids are a finite resource, and the deficiency of cannabinoids can result in headaches, irritability, and other health issues).
There are actually hundreds of case studies supporting CBD as an effective treatment for dozens of conditions (review the full list of CBD case studies here).
Cannabis compounds exist for a reason and it’s no accident that we have an Endocannabinoid System that is directly linked to It.
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9. De Laurentiis A, Araujo HA, Rettori V. Role of the endocannabinoid system in the neuroendocrine responses to inflammation. Curr Pharm Des. 2014;20(29):4697-4706.
10. McPartland JM, Matias I, Di Marzo V, Glass M. Evolutionary origins of the endocannabinoid system. Gene. 2006;370:64-74.doi:https://doi.org/10.1016/j.gene.2005.11.004.
From Goldleaf The Endocannabinoid System: Why Our Bodies Respond To Cannabis – Goldleaf